WebThe NKRP1 receptor family and their ligands (CLEC2 subfamily) are of great interest because they are conserved in human and mouse and can mediate surveillance of missing-self (reviewed in (Bartel ... WebJun 3, 2024 · CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C-type lectin receptors, abundantly expressed by leukocytes and platelets, respectively. Whereas CLEC5A is a pattern recognition receptor...
Interaction of C-type lectin-like receptors NKp65 and KACL …
WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … WebNational Center for Biotechnology Information grignoter traduction
Platelet CLEC-2: Roles Beyond Hemostasis - PubMed
Webmember of the human CLEC2 family of CTLRs. In contrast to the other CLEC2 family members AICL, CD69, and LLT1, KACL expres-sion is mostly restricted to skin. Here we show that KACL is a non– disulfide-linked homodimeric surface receptor and stimulates cyto-toxicity by human NK92MI cells. We identified the corresponding WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … WebNotably, CLEC2 and NKRP1 molecules not only share the same fold, but are also genetically linked in the NKC. Recent research efforts began to systematically elucidate the expression and function of the numerous NKRP1 and CLEC2 family members in rodents and revealed previously unnoticed corresponding receptor/ligand pairs in humans. grignon law firm llp