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Clec2 family

WebThe NKRP1 receptor family and their ligands (CLEC2 subfamily) are of great interest because they are conserved in human and mouse and can mediate surveillance of missing-self (reviewed in (Bartel ... WebJun 3, 2024 · CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C-type lectin receptors, abundantly expressed by leukocytes and platelets, respectively. Whereas CLEC5A is a pattern recognition receptor...

Interaction of C-type lectin-like receptors NKp65 and KACL …

WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … WebNational Center for Biotechnology Information grignoter traduction https://bignando.com

Platelet CLEC-2: Roles Beyond Hemostasis - PubMed

Webmember of the human CLEC2 family of CTLRs. In contrast to the other CLEC2 family members AICL, CD69, and LLT1, KACL expres-sion is mostly restricted to skin. Here we show that KACL is a non– disulfide-linked homodimeric surface receptor and stimulates cyto-toxicity by human NK92MI cells. We identified the corresponding WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … WebNotably, CLEC2 and NKRP1 molecules not only share the same fold, but are also genetically linked in the NKC. Recent research efforts began to systematically elucidate the expression and function of the numerous NKRP1 and CLEC2 family members in rodents and revealed previously unnoticed corresponding receptor/ligand pairs in humans. grignon law firm llp

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Category:CLEC-2 is an essential platelet-activating receptor in hemostasis …

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Clec2 family

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WebRequest Bulk Quote. Description. C-type lectin domain family 1 member B (CLEC1B, CLEC2) is a 32kD, type II transmembrane protein, highly expressed on platelets and megakaryocytes. CLEC1B is involved in platelet activation and aggregation, and mediates the capture of HIV-1 by platelets. CLEC1B contains one hem-immunoreceptor tyrosine … WebRather, at least some mouse NKRP1 receptors ligate members of the CLEC2 family with NKRP1 and CLEC2 genes interspersed in a distinct subregion of the NKC establishing a …

Clec2 family

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WebMay 24, 2024 · Hello, I Really need some help. Posted about my SAB listing a few weeks ago about not showing up in search only when you entered the exact name. I pretty … WebMar 29, 2024 · CLEC-2 is the first member of the C-type lectin family of receptors identified to stimulate platelet aggregation through a tyrosine kinase-dependent pathway. (Review) …

WebJan 5, 2015 · CLEC2 is also a receptor for the endogenous platelet activator podoplanin (PDPN; 608863). Using protein binding experiments, Suzuki-Inoue et al. (2010) found … WebC-type lectin domain family 1 member B (UniProt Q9P126; also known as C-type lectin-like receptor 2, CLEC-2) is encoded by the CLEC1B (also known as CLEC2, UNQ721/PRO1384) gene (Gene ID 51266) in human. CLEC-2 is a type II single-transmembrane (a.a. 34-54) protein with a large extracellular (a.a. 55-229) region that …

WebJun 11, 2013 · While many CLEC2 family members are expressed by hematopoietic cells (e.g. CD69 (CLEC2C)), others such as the keratinocyte-associated KACL (CLEC2A) are …

WebSep 22, 2024 · CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed …

WebCLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L … fife luxury cottagesWebMay 22, 2015 · Interactions between podoplanin (PDPN) and C-type lectin domain family 1 member B (commonly known as CLEC2) are crucial checkpoints for FRC development 24,25, as Pdpn −/− and Clec1b −/− ... grignolino food pairingWebNov 29, 2007 · These C-type lectin-like receptors (CTLR) mostly are homo- or heterodimers of type II transmembrane proteins and contain a single extracellular C-type lectin-like … grignote in englishWebJun 11, 2024 · CLEC2 is a Syk-CLR that is specifically expressed in human platelets. Human CLEC2 encodes a 229–amino acid type II transmembrane protein, comprising a C-type lectin domain in the C-terminus, and a single YxxL motif (hemITAM) in the intracellular domain located at the N-terminus [ 60, 61 ]. fife luxury travelWebJun 2, 2014 · This family of receptors is somewhat unique within the NKC, because their ligands are other C-type lectin-related proteins (Clr; encoded by the Clec2 genes), and … grignotage 0 point wwWebJun 2, 2014 · This family of receptors is somewhat unique within the NKC, because their ligands are other C-type lectin-related proteins (Clr; encoded by the Clec2 genes), and the Clr/Clec2 loci are genetically interspersed amongst the Nkrp1/Klrb1 receptor genes themselves ( 18 – 20) (Figure 1 ). fife managerWebCLEC2 acts as a receptor for rhodocytin, a platelet-aggregating protein found in snake venom. CLEC2 expression is not restricted to platelets and also acts as an activation receptor on neutrophils. Product Details Target Species Mouse Product Form Purified IgG - liquid Preparation fife mash