WebMar 9, 2024 · Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. In repetitive strain injury, substance P immunoexpression increased in week 12 peritendon as did CTGF-immunopositive fibroblasts. CTGF expression in epithelium was up-regulated early and urinary CTGF was markedly elevated from … WebMar 6, 2024 · TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. ... Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs. Am J Physiol Lung Cell Mol Physiol 292: L223–L231, 2007. doi: 10.1152/ajplung.00159.2006.
TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis
WebApr 9, 2024 · Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the signal transduction of angiotensin II receptor (ATR) for upregulation of TGF-β1 and ET-1, and their effectors that play an essential role in myofibroblast … WebJan 8, 2024 · TGFβ signaling has attracted the interest of cancer biologists because of its numerous roles in regulating cancer cell functions, including cell cycle progression, … how many bullets in a glock 18
TGF-Beta Signaling: Methods and Protocols SpringerLink
The primary cultures of orbital fibroblasts were established from surgical specimens of 4 patients with GO (G1-G4) during decompression surgery (one men and three women; mean age: 37.2 years) and from apparently normal orbital tissues in four age- and sex-matched patients (N1-N4), who received surgery for … See more The recombinant human TGF-β1 (#P01137) and TGF-β2 (#P61812) were purchased from R&D Systems, Inc. (Minneapolis, MN, USA), and the recombinant human CTGF protein (#PHG0286) was … See more The intracellular contents of human transforming growth factor-beta 1 (TGF-β1; catalog #DB100B) was quantified in cell culture supernatant by an enzyme-linked … See more About 1 × 107 cells were trypsinized, pelleted, washed with PBS, and then resuspended in the lysis buffer containing 50 mM Hepes (pH 7.4), 4 mM EDTA, 2 mM EGTA, 1 mM Na3VO2, 1 mM NaF, 1% Triton X-100, and … See more The small hairpin RNA (shRNA) plasmids for the CTGF gene (shCTGF) and luciferase control gene (shLuc) were obtained from the RNAi Core Facility at Academia Sinica, Taipei, Taiwan. The shLuc and shCTGF … See more WebThe TGF beta signaling pathway plays an important role in the development, homeostasis, and repair of most tissues in organisms. All immune cell lineages, including B-cell, T-cell, and dendritic cells as well as macrophages, secrete TGF beta, which negatively regulates their proliferation, differentiation, and activation by other cytokines. WebTransforming growth factor beta (TGF-beta) signaling pathway is a series of signal transduction processes mediated by transforming growth factor. TGF-β signaling … high pulse pressure indicates