Web11 de abr. de 2024 · Moreover, the levels of HIF-1α, p-Pyk2 and p-ERK1/2 were positively correlated with TMEM237 expression ... Additionally, IHC staining results revealed that TMEM237 overexpression increased p-Pyk2 and p-ERK1/2 levels, while TMEM237 knockdown decreased the levels of p-Pyk2 and p-ERK1/2 in xenograft tumor tissues (P < … Web22 de jan. de 2024 · Together, we have demonstrated that HER2 overexpression in this model is able to increase the hypoxic upregulation of HIF-2α and functionally important …
Hif-1α Knockdown Reduces Glycolytic Metabolism and …
WebHIF- and HIF- play critical but nonoverlapping roles in tumor progression [ ,]. Recent studies have shown that TWISTandCXCR aretwodirecttargetgenesofHIF- , HIF- can activate the … Web23 de out. de 2024 · The mechanism of HIF-2 activation by FPN overexpression in IEC-6 cells was the same as in HEK293 cells, ... Schematic representation of hepatic hepcidin/intestinal HIF-2 axis. Male samples are designated as squares, and female samples are designated as circles. how to reset character in dauntless pc
HIF-1 versus HIF-2 — Is one more important than the other?
Web4 de set. de 2024 · Hypoxia-inducible factor 1α (HIF-1α) is essential in hepatocellular carcinoma (HCC) glycolysis and progression. Yes-associated protein (YAP) is a powerful regulator and is overexpressed in many cancers, including HCC. The regulatory mechanism of YAP and HIF-1α in HCC glycolysis is unknown. We detected YAP expression in 54 … Web19 de jun. de 2024 · Furthermore, HIF-1α overexpression increased the levels of TGF-β and induced Smad2/3 activation compared with control (Figure 5G). Consistently, HIF-1α overexpression could increase the expression level of profibrotic marker α-SMA, Collagen-I, and TIMP-1 in LX-2 cells transfected with Sh-HLF or miR-98 mimics (Figure 5H). Web10 de mar. de 2014 · HIF-1α overexpression has been linked to poor gastric cancer prognosis. However, though researched for years, the prognostic role of HIF-1α in gastric cancer is still controversial. Hence, the objective of the present study was to analyze the prognostic values of HIF-1α, TGF-β, VEGF and pERK1/2 in gastric cancer patients … north carolina road cams